Why is Real-World Evidence (RWE) important?
Real-World Evidence refers to any piece of healthcare information derived from real-world data sources beyond clinical trial settings. In this video, Entela Xoxi, from Università Cattolica del Sacro Cuore (Italy) and former AIFA, speaks about the importance of RWE in medicines development and in the healthcare decision-making process.
This video is one of a series of short experts’ talks, sponsored by Biogen, on real-world evidence and comparative studies’ methodologies.
Registries in Multiple Sclerosis
Registries are databases resulting from prospective, observational cohort studies of patients who have a particular disease and/or are receiving a particular treatment or intervention. In this video, Dr. Ali Manouchehrinia, from Karolinska Institutet (Sweden), speaks about the advantages and limitations of registries as a source of real-world data and gives an overview of some existing registries collecting Multiple Sclerosis specific data in Europe.
This video is one of a series of short experts’ talks, sponsored by Biogen, on real-world evidence and comparative studies’ methodologies.
Claims Databases and Real-World Evidence
Claims databases are database systems built on data extracted from claims that are submitted by healthcare providers to payers when a patient uses health services. The data, collected for administrative or billing purposes, can also be used to determine the effectiveness of treatments in real-world settings, health care delivery, costs, benefits, and associated safety/adverse events. In this video, Dr. Patrick Blin, from Bordeaux University (France), speaks about the advantages and limitations of healthcare insurance claims analyses and gives some concrete examples of their use as sources of real-world evidence.
This video is one of a series of short experts’ talks, sponsored by Biogen, on real-world evidence and comparative studies’ methodologies.
Indirect Comparisons: Methods and Validity
There are many methods that can be used to carry out indirect comparisons of treatments. These methods make it possible to obtain data on the relative efficacy and safety of different competing treatments in the complete or partial absence of direct comparison trials of these treatments. In this video, Dr. Carsten Schwenke, from Sco:ssis (Germany), speaks about the different methods used to carry out indirect comparisons and their validity.
This video is one of a series of short experts’ talks, sponsored by Biogen, on real-world evidence and comparative studies’ methodologies.